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KMID : 1038820150180040246
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Pediatric Gastroenterology, Hepatology & Nutrition
2015 Volume.18 No. 4 p.246 ~ p.252
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Association between Gastric pH and Helicobacter pylori Infection in Children
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Seo Ji-Hyun
Park Heung-Keun
Park Ji-Sook
Yeom Jung-Sook
Lim Jae-Young
Park Chan-Hoo
Woo Hyang-Ok
Youn Hee-Shang
Jun Jin-Su
Ko Gyung-Hyuck
Baik Seung-Chul
Lee Woo-Kon
Cho Myung-Je
Rhee Kwang-Ho
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Abstract
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Purpose: To assess gastric pH and its relationship with urease-test positivity and histological findings in children with Helicobacter pylori infection.
Methods: Fasting gastric juices and endoscopic antral biopsy specimens were collected from 562 children and subjected to the urease test and histopathological examination. The subjects were divided into 3 age groups: 0-4, 5-9, and 10-15 years. The histopathological grade was assessed using the Updated Sydney System, while the gastric juice pH was determined using a pH meter.
Results: The median gastric juice pH did not differ significantly among the age groups (p=0.655). The proportion of individuals with gastric pH ＞4.0 was 1.3% in the 0-4 years group, 6.1% in the 5-9 years group, and 8.2% in 10-15 years (p=0.101). The proportions of moderate and severe chronic gastritis, active gastritis, and H. pylori infiltration increased with age (p＜0.005). Urease-test positivity was higher in children with hypochlorhydria (77.8%) than in those with normal gastric pH (31.7%) (p＜0.001). Chronic and active gastritis were more severe in the former than the latter (p＜0.001), but the degree of H. pylori infiltration did not differ (20.9% vs. 38.9%; p=0.186).
Conclusion: Gastric pH while fasting is normal in most children regardless of age. Urease-test positivity may be related to hypochlorhydria in children, and hypochlorhydria is in turn related to H. pylori infection.
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KEYWORD
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Urease test, Helicobacter pylori, Child, Gastric juice, Hypochlorhydria
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